Etheridge was born in 1866 and married J. D. Etheridge, a wealthy Bosque County, Texas, farmer and widower with eight children, in 1912. She was reported to be his second wife and to have resented the attention he gave the children.
In June and October 1913 four of the children died: two in June and two in October, of what was recorded as illness at the time. Arsenic was found after the fourth death and the earlier bodies were examined.
She pleaded guilty and was sentenced to life imprisonment on December 23, 1913, the whole matter concluding within weeks of the last death.
The accessible record is Texas press reporting of 1913 and the summaries that descend from it. A date range of 1912 to 1913 is sometimes read as her lifespan; those are the years of the marriage and the killings. She was born in 1866.